England, who had finished Day 2 of the fourth test at 6/0, started proceeding on the Day 3 at Southampton as they were trailing by 21 runs.
The opening pair of Alastair Cook and Keaton Jennings saw the intial half an hour through without any alarms, but Jasprit Bumrah provided the visitors a much needed breakthrough by getting rid of Cook who was caught at slip by Lokesh Rahul for 12 runs.
Moeen Ali who was promoted at no 3, failed to grab the opportunity as he fell to Ishant Sharma.
Skipper Joe Root and Jennings consolidated and added a partnership of 59 runs to bring them back on track, but Mohammed Shami struck twice, first by getting rid of the Lancashire left hander before lunch for 36 and Jonny Bairstow for a duck.
Shami then ran out Root for 48 with a direct hit from mid on to reduce England to 122/5.
Jos Buttler played a crucial of 69 runs knock before he fell to Ishant Sharma post tea. His innings comprised of seven fours.
The ODI Wicketkeeper batsman stitched a vital 55 run stand for the seventh wicket stand with Sam Curran,to keep the Indian bowlers at bay.
Edgbaston hero Curran (37)* made yet another significant contribution with the bat as hosts England ended Day 3 at 260/8, with an overall lead of 233 runs.
Adil Rashid fell to the final delivery of third day’s play for 11 runs.
Mohammed Shami was the pick of the Indian bowlers with figures of 3/53.